Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis
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چکیده
منابع مشابه
Amyotrophic Lateral Sclerosis in a Patient with Behçet’s Disease
Behçet’s disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...
متن کاملProtein Aggregates in Pathological Inclusions of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is characterized by a progressive loss of upper and/or lower motor neurons (Bruijn et al., 2004). Dysfunction and death of these neurons lead to muscle weakness, atrophy and spasticity. A fatal event for the majority of patients is a failure of the respiratory muscles, which generally occurs within one to five years of dis...
متن کاملFUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
OBJECTIVE Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration. Most cases of ALS are sporadic (SALS), but about 5 to 10% of ALS cases are familial (FALS). Recent studies have shown that mutations in FUS are causal in approximately 4 to 5% of FALS and some apparent SALS cases. The pathogenic mechanism of the mutant FUS-mediated ALS and potential roles of FUS in n...
متن کاملAmyotrophic Lateral Sclerosis and Novel Therapeutic Strategies
1Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA 2Department of Neurosciences, University of Toledo Medical Center, Toledo, OH 43614, USA 3Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA 4Department of Neurology, Hannover Medical School, Hannover, 30625, Germany 5Center for Translational Neuroscience, Department of Neurobio...
متن کاملAmyotrophic lateral sclerosis, Parkinson's disease, and the amyotrophic lateral sclerosis-Parkinsonism-dementia complex on Guam: a review and summary of attempts to demonstrate infection as the aetiology.
In a series of lectures delivered in 1874, Charcot described a new syndrome which he termed amyo-trophlc lateral sclerosis (ALS). At that time he presented the essential pathological and classical characteristics of the disease which, although later modified and refined by himself and subsequent workers, have remained remarkedly classical for ALS during the almost 100 years since they were publ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.202100137r